TDM in children with IBD

Therapeutic Drug Monitoring is a new tool for improving the care of patients treated by antiTNFalpha: does this apply to children with Inflammatory Bowel Diseases?

  1. Abstract
  2. Poster: PDF
  3. List of references :
    1.Kelsen J, Baldassano RN. Inflammatory bowel disease: the difference between children and adults. Inflamm Bowel Dis. 2008;14 Suppl 2:S9-11. doi: 10.1002/ibd.20560. PubMed PMID: 18816756.
    2.Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002;359(9317):1541-9. doi: 10.1016/S0140-6736(02)08512-4. PubMed PMID: 12047962.
    3.Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005;353(23):2462-76. doi: 10.1056/NEJMoa050516. PubMed PMID: 16339095
    4.Hyams J, Crandall W, Kugathasan S, Griffiths A, Olson A, Johanns J, et al. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn’s disease in children. Gastroenterology. 2007;132(3):863-73; quiz 1165-6. doi: 10.1053/j.gastro.2006.12.003. PubMed PMID: 17324398.
    5.Maser EA, Villela R, Silverberg MS, Greenberg GR. Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn’s disease. Clin Gastroenterol Hepatol. 2006;4(10):1248-54. doi: 10.1016/j.cgh.2006.06.025. PubMed PMID: 16931170.
    6.Paul S, Del Tedesco E, Marotte H, Rinaudo-Gaujous M, Moreau A, Phelip JM, et al. Therapeutic drug monitoring of infliximab and mucosal healing in inflammatory bowel disease: a prospective study. Inflamm Bowel Dis. 2013;19(12):2568-76. doi: 10.1097/MIB.0b013e3182a77b41. PubMed PMID: 24013361.
    7.Singh N, Rosenthal CJ, Melmed GY, Mirocha J, Farrior S, Callejas S, et al. Early infliximab trough levels are associated with persistent remission in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2014;20(10):1708-13. doi: 10.1097/MIB.0000000000000137. PubMed PMID: 25153505.

Lancement de l’étude ViDiPeC : Vitamin D in Pediatric Crohn’s Disease

The Vitamin D in Pediatric Crohn’s Disease is multicentric Randomized Controlled Trial of High Dose Vitamin D in Children With Newly Diagnosed Crohn’s Disease for the Prevention of Relapses. https://clinicaltrials.gov/ct2/show/record/NCT02186275

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This study have been approved by Health Canada and is supported by the Canadian Children Inflammatory Bowel Disease Network (CiDSCANN) and Crohn’s and Colitis Canada.

IBD database | Base de données sur les MII

Building a database for inflammatory bowel disease:

Sans titre

Here are the three parts video of the webinar about building a database for IBD

PART1: Why, How and when

Part 2: Live Demo

Part 3: Security and Filemaker server

 

For those who are interested in acquiring a license of the database, please feel free to contact us by using the following form.

 

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