Archives dans mars 2016

TDM in children with IBD

Therapeutic Drug Monitoring is a new tool for improving the care of patients treated by antiTNFalpha: does this apply to children with Inflammatory Bowel Diseases?

  1. Abstract
  2. Poster: PDF
  3. List of references :
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    2.Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial. Lancet. 2002;359(9317):1541-9. doi: 10.1016/S0140-6736(02)08512-4. PubMed PMID: 12047962.
    3.Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005;353(23):2462-76. doi: 10.1056/NEJMoa050516. PubMed PMID: 16339095
    4.Hyams J, Crandall W, Kugathasan S, Griffiths A, Olson A, Johanns J, et al. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn’s disease in children. Gastroenterology. 2007;132(3):863-73; quiz 1165-6. doi: 10.1053/j.gastro.2006.12.003. PubMed PMID: 17324398.
    5.Maser EA, Villela R, Silverberg MS, Greenberg GR. Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn’s disease. Clin Gastroenterol Hepatol. 2006;4(10):1248-54. doi: 10.1016/j.cgh.2006.06.025. PubMed PMID: 16931170.
    6.Paul S, Del Tedesco E, Marotte H, Rinaudo-Gaujous M, Moreau A, Phelip JM, et al. Therapeutic drug monitoring of infliximab and mucosal healing in inflammatory bowel disease: a prospective study. Inflamm Bowel Dis. 2013;19(12):2568-76. doi: 10.1097/MIB.0b013e3182a77b41. PubMed PMID: 24013361.
    7.Singh N, Rosenthal CJ, Melmed GY, Mirocha J, Farrior S, Callejas S, et al. Early infliximab trough levels are associated with persistent remission in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2014;20(10):1708-13. doi: 10.1097/MIB.0000000000000137. PubMed PMID: 25153505.